IgA nephropathy
Conditions
Interventions
Two groups:ramipril 5 years versus no treatment
Sponsors
The Chinese University of Hong Kong
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Inclusion criteria are: ? age between 18 and 65 ? biopsy-confirmed IgA nephropathy ? proteinuria less than 0.5 g per day, normal blood pressure, and serum creatinine below 120 mol/l ? willingness to give written informed consent and willingness to participate in and comply with the study protocol
Exclusion criteria
Exclusion criteria: Exclusion criteria are: 1. expected survival less than 2 years; 2. pregnant or nursing mother, or women of childbearing potential without an effective method of birth control; 3. history of myocardial infarction, congestive heart failure, or any other medical indication that necessitate the use of ACE inhibitor ? evidence of clinically significant hepatic, gastrointestinal, autoimmune disease; 4. history of malignancy, drug or alcohol abuse; 5. participation in any previous trial on ACE inhibitor; 6. taking other investigational drugs within the past 30 days; 7. history of non-compliance to medical regimens and patients who are considered potentially unreliable ? known history of sensitivity / allergy to ACE inhibitor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| development of hypertension (defined as blood pressure above 140/90 mm Hg and require anti-hypertensive therapy);development of proteinuria ?d 1 g per day;20% decline in creatinine clearance, as determined by 24-hour urine collection or estimated by the Gault-Cockroft equation; | — |
Countries
China
Contacts
Public ContactDr. SZETO Cheuk Chun
Outcome results
None listed