living donor kidney transplantation
Conditions
Interventions
Group A:Prograf (routine)+MMF+corticosteroids
Group B:Prograf (pretreatment)+Progrof (routine)+MMF+corticosteroids
Sponsors
309 Hospital of Chinese PLA
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 to 65 years old; 2. Both male and female are eligible; 3. Body weight ranges from 45 kg to 90 kg; 4. Recipients of a first kidney transplant; 5. A negative pregnancy test prior to receiving study medication; 6. Women of childbearing potential are willing to use contraception; 7. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Re-transplantation or transplantation other than kidney; 2. ABO incompatible transplantation; 3. Antibody induction therapy is required prior to transplantation; 4. PRA>10%; 5. Severe hepatic disease. Defined as: SGPT/ALT, SGOT/AST or total bilirubin increase to more than twice of normal level within 28 days before transplantation; 6. Uncontrolled infection; 7. Severe diarrhea or vomiting, active upper peptic ulcer or malabsorption; 8. Severe cardiac, pulmonary diseases, impaired glucose tolerance or history of malignancy; 9. Allergy to tacrolimus, MMF; 10. Pregnancy or lactation woman.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recipient survival rate;Graft survival rate;Acute rejection or biopsy confirmed acute rejection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Delayed graft function (DGF) rate;Renal function (Creatinine clearance and serum cretine); | — |
Countries
China
Contacts
Public ContactBingyi Shi
Outcome results
None listed