atrial fibrillation
Conditions
Interventions
Group A:circumferential pulmonary vein ablation+atrial linear ablation (left atrial roof, mitral isthmus and cavo-tricuspid isthmus)
Group B:circumferential pulmonary vein ablation+atrial linear ablation (left atrial roof, mitral isthmus and cavo-tricuspid isthmus) +complex fractionated atrial electrogram (CFAE) ablation
Sponsors
Beijing Anzhen Hospital affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years old; 2. Experienced twice persistent symptomatic AF episodes documented by ECG with an interval of at least 7 days in latest 6 months; 3. With symptomatic AF respondent to amiodarone; 4. Had willingness, ability and commitment to participate in follow-up.
Exclusion criteria
Exclusion criteria: 1. Experienced coronary artery bypass graft surgery within 1 year of screening; 2. With uncontrolled congestive heart failure; 3. Having significant valvular disease and/or prosthetic heart valve(s); 4. With myocardial infarction or stroke within 3 months of screening; 5. With Significant congenital heart disease; 6. Ejection fraction was <35% measured by echocardiography; 7. Allergic to contrast media; 8. Severe electrolyte abnormalities within 1 month of treatment; 9. Contraindication to warfarin or heparin; 10. Pulmonary emboli or stroke within 1 year before screening; 11. Left atrial (LA) thrombus measured by pre-procedure transesophageal echocardiography; 12. Pregnant women; 13. having any contraindication to right or left sided heart catheterization; 14. Poor general health ; 15. Life expectancy less than 1 year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Conversion proportion to sinus rhythm after initial ablation procedure (including either by cardiove; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of complications;Atrial fibrillation- and atrial flutter- free proportion without antiarrhythmic-drug adnimistration; | — |
Countries
China
Contacts
Public ContactChangsheng Ma
Outcome results
None listed