Hepatocellular carcinoma and cirrhosis
Conditions
Interventions
B:Hepatectomy combined with splenectomy
Sponsors
Third Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Liver cirrhosis diagnosed by fibration grade F3 or F4 by means of puncture biopsy or postoperative pathology; 2. Primary hepatocellular carcinoma by means of postoperative pathology; 3. Liver function: Child-A or Child-B, ICG-R15<14%; 4. Technically radical neoplasm excision; 5. Portal hypertension: splenomegaly (the thickness of spleen is more than 4.1cm by means of percataneous ultrasonography or computerized tomography) and hypersplenism (WBC<4.0*10^9/L or PLT<100*10^9/L); 6. Patients with slight or moderate grade of esophageal and gastric varices by means of endoscopy, without hematemesis, and never received endoscopic varicose vein ligation or variceal sclerotherapy.
Exclusion criteria
Exclusion criteria: 1. Preoperative examinations show tumor thrombus in main portal vein and its first branches, common hepatic duct and its first branches, main hepatic veins, and hepatic veins; 2. Neoplasm metastasis out of liver or in lymph nodes; 3. Pathology shows active hepatitis; 4. Chemotherapy or interventional therapy or any other adjunctive therapy before operation; 5. Patients complicated with diabetes mellitus or heart diseases or any other organ diseases, can't tolerate the surgery; 6. Obstructive jaundice; 7. Postoperative recurrence in 2 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease free survival;Overall survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peri-operative complication, biochemical indices of liver function (0d, 1d, 3d,7d, 14d), AFP (7d,14d); | — |
Countries
China
Contacts
Public ContactFeng Xia
Outcome results
None listed