Generalized convulsive status epilepticus
Conditions
Interventions
group A:Diazepam 10mg intravenous, followed by infusion at the initial rate of 4mg/h, then increased by 4mg every 5min until SE is controlled or persisting for1 hour
group B:Sodium valproate 30mg/kg intravenous, followed by infusion at the rate of 1-2mg/kg/h
Sponsors
Xuanwu Hospital of the Capital Medical University
Eligibility
Sex/Gender
All
Age
15 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male and female aged 15 years old and over; 2. The authorized principal is able and willing to provide signed informed consent; 3.Generalized convulsive status epilepticus, meeting the criterion formulated by Epilesy Foundation of America's Working Group on Status Epilepticus in 1993: More than 30 minutes of continuous seizure activity or two or more sequential seizures without full recovery of consciousness between seizures.
Exclusion criteria
Exclusion criteria: 1. Pregnant women or lactating parturient; 2. Cranium trauma; 3. Systemic disease: liver and/or kidney function insufficiency; 4. Allergic to target drug (sodium valproate or diazepam).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Times of breakthrough seizures within 24 hours;Time interval between starting the study drug and the control of SE;Response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| The neurological outcome; | — |
Countries
China
Contacts
Public ContactYingying Su
Outcome results
None listed