Extensive chronic graft versus host disease
Conditions
Interventions
A:Glucocorticoids+CSA/FK506
B:Glucocorticoids+CSA/FK506+MSC
Sponsors
Sun Yat-sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Informed consent obtained from patient and donor; 2. Any patient who has undergone allogeneic stem cell transplantation with extensive chronic GVHD; 3. Have not received additional agent for cGVHD within 3 months; 4. Expected life is more than 90 days; 5. Adequate pulmonary function with no evidence of chronic obstructive or severe restrictive pulmonary disease; 6. Adequate cardiac function with no evidence of uncontrolled high blood pressure,congestive heart failure, angina pectoris, acute myocardial infarction within 6 months prior to the process.
Exclusion criteria
Exclusion criteria: 1. Invasive fungal disease; 2. Active cytomegalovirus (CMV)/Epstein-Barr virus(EBV)/varicella disease); 3. Patient is with a history of hypersensitivity to bovine products; 4. Relapsed malignancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Remission rate (CR and PR);Safety of MSC treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect on OS, DFS and QOL;The total Response rate; | — |
Countries
China
Contacts
Public ContactXin Du
Outcome results
None listed