Rheumatoid Arthritis
Conditions
Interventions
A:LEF 10mg qd + HCQ 0.2 bid.
B:LEF 10mg qd
Sponsors
Peking University People's hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Male and female aged 18 to 65 years old; 2. RA patients with active disease;1) Diagnosed based on the 1987 revised American College of Rheumatology (ACR) criteria for RA: (1) Morning stiffness>=1h; (2) Arthritis of three or more joint areas, >=6 weeks; (3) Arthritis of hand joints, >=6 weeks; (4) Symmetric arthritis, >=6 weeks; (5) Rheumatoid nodules; (6) Serum rheumatoid factor; (7) Radiographic changes. Satisfied at least four of these seven criteria; 2. The DAS28 score more than 5.1 is defined as active disease; 3. To be able to and willing to provide signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergy to leflunomide(LEF),methotrexate(MTX) and hydroxychloroquine(HCQ); 2. Stage IV of joints according to the American College of Rheumatology(ACR); 3. Body Weight =10mg/d within 1 month before enrolment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The efficiency and recurrence rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lab test;Clinical symptoms and signs;Sharp score;The doctor's and the patient's self assessmen; | — |
Countries
China
Contacts
Public ContactZhanguo Li
Outcome results
None listed