A randomized, controlled trial to evaluate the safety and efficacy of losartan in obvious proteinuria patients with lower-normal blood pressure

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-09000462

Enrollment

Unknown

Registered

2009-06-09

Start date

2009-07-05

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CKD with obvious proteinuria

Interventions

A:None

B:Losartan 25-50mmHg

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 70 years old; 2. Able and willing to provide signed informed consent; 3. 24 hours urine protein>=0.5g; 4. Blood pressure <=110/70mmHg or MBP<=85mmHg.

Exclusion criteria

Exclusion criteria: 1. Patients who are taking antihypertensive medcines, steroid or immunosuppressor; 2. 24 hours urine protein>=3.5g or serum albumin <30G/L; 3. eGFR<=30ml/min; 4. Liver function insufficient; 5. Patients with hypovolemia, serious edema, AKI; 6. Patients who have previous cancer treatments; 7. Uncontrolled heart failure/infection; 8. Pregnancy or lactating woman; 9. Patients with history of allergy of Losartan.

Design outcomes

Primary

Measure	Time frame
24 hours proteinurin;	—

Secondary

Measure	Time frame
Blood pressure;	—

Countries

China

Contacts

Public ContactLeyi Gu

guleyi2006@yahoo.com.cn+86 021 53882021

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026