Congenital heart disease
Conditions
Interventions
Group A:three 5-min cycles of lower limb ischemia and reperfusion using a blood pressure cuff inflated to a pressure 15 mmHg greater than the systolic arterial pressure of the cprresponding lim.
Group B:sham placement of the blood pressure cuff around the leg without inflation.
Sponsors
Department of Anesthesiology, Union Hospital, Wuhan, Hubei, China
Eligibility
Sex/Gender
All
Age
No minimum to 3 Years
Inclusion criteria
Inclusion criteria: 1. 3months to 3 years age; 2. waiting for elective surgical correction of congenital heart disease; 3. RACHS-1 grade, anticipated CPB time greater than 1 hour; 4. informed consent form from the parent or guardian.
Exclusion criteria
Exclusion criteria: 1. presence of a major noncardiac structural anomaly; 2. peripheral vascular disease; 3. systemic complications such as severe anemia, pulmonary infection; 4. diabetes mellitus; 5. pre-existing renal insufficiency; 6. Perioperative use of nephrotoxic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Acute Kidney Injury(AKI) and myocardial injury;Mitochondria damage in ultrastructural pathology;pAkt pStat3 peNO; | — |
Secondary
| Measure | Time frame |
|---|---|
| parameters associated with hemodynamics, liquid supplement, urine volume, vasoactive drugs and furos; | — |
Countries
China
Contacts
Public ContactQingping Wu
Outcome results
None listed