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Efficacy and safety of heparin inhalation on acute lung injury: multi-center, prospective, randomized controlled study

Efficacy and safety of heparin inhalation on acute lung injury: multi-center, prospective, randomized controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-TRC-09000431
Enrollment
Unknown
Registered
2009-05-25
Start date
2009-07-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute lung injury (ALI)

Interventions

B:Sterile water for injection 5ml, inhalation, q12h, for 7 days
A:Heparin 50000IU/5ml inhalation, q12h, for 7 days

Sponsors

Intensive Care Unite of West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Acute episode; 2. X-ray showed the infiltration; 3. PaO2/FiO2)<=40kPa(300mmHg); 4. Pulmonay Wedge Pressure<=2.4kPa(18mmHg) or without clinical evidence of increased left atrial pressure.

Exclusion criteria

Exclusion criteria: 1. Diagnosis of ALI was confirmed after 48 hours; 2. Hypoxemia caused by congestive heart failure, pulmonary embolism, chronic obstructive pulmonary disease, asthmas and et al; 3. Systemic coagulation dysfunction: blood purification therapy, pneumorrhagia, active bleeding diseases in the past 3 months and thrombocytopenia caused by heparin allergy; 4. Ecpected survival time<96 hours; 5. Pregnancy.

Design outcomes

Primary

MeasureTime frame
Mortality rate in 28 days;SPa2, FIO2;Coagulation index (PT, APTT, TCT, FIB);—

Secondary

MeasureTime frame
Hospital saty;Alveolar dead space;Lung complianc;—

Countries

China

Contacts

Public ContactZhongwei Zhang
zhangzhongwei1@medmail.com.cn+86 13308203057

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026