Multiple Organs Dysfunction Syndrome
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. With the diagnosis of MODS in accordance with the standard diagnostic criteria (dysfunction of more than 2 organs); 2. With the diagnosis of SIRS or sepsis in accordance with the standard diagnostic criteria.
Exclusion criteria
Exclusion criteria: 1. HIV infection; 2. Pregnancy, organ transplantation recipient within 1 year or cachexia; 3. Allergy of cardiopulmonary circulation,anticoagulant or blood purification equipments; 4. Cannot undergo blood purification treatment because of other diseases or having severe complications during treatment; 5. Patients having other diseases which may influence the outcome, eg.rheumatic diseases,severe autoimmune diseases; 6. Cannot cooperate effectively during treatment; 7. Involved in other clinical trails; 8. Considered not suitable for the trail by doctors(at least 2 attendings)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| vital signs;cytokines (TNF-alpha, IL-1 beta, IL -6, IL-10);APACHE score;mortality;rennal function;adverse reaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| short-term mortality; | — |
Countries
China