Prospective controlled trial on perioperative glutamine in hepatectomy of primary liver cancer

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-09000429

Enrollment

Unknown

Registered

2009-01-10

Start date

2008-12-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatectomy of primary liver cancer with cirrhosis

Interventions

A:Postoperative TPN with 2% glutamine 200ml for 1 week

B:Postoperative TPN without glutamine for 1 week

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed as primary liver cancer without metastasis is scheduled to hepatectomy; 2. Complicated with cirrhosis; 3. Liver function: Child-Pugh Grade A-B; 4. EGOS scores 0-2.

Exclusion criteria

Exclusion criteria: 1. Unable to sign the informed consent or follow up occasionally; 2. Glutamine allergy; 3. Failed to accept hepatectomy during surgery; 4. Accompanied with splenectomy or portal hypertension surgery; 5. Severe gastric esophageal varices confirmed by X ray or endoscopy; 6. Complicated with heart dysfunction or other severe associated diseases

Design outcomes

Primary

Measure	Time frame
Incidence rate of infectious complication;	—

Secondary

Measure	Time frame
Progression-free survival (PFS);Value of plasma prealbumin after 1 week;Postoperative hospital stay;	—

Countries

China

Contacts

Public ContactTong Kan

kanto168.888@vip.163.com+86 021 81875542

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026