Colorectal cancer
Conditions
Interventions
B:Placebo, orally taken for 16 days (from 6 days before the operation
one day after operation, the intervention continues for another 10 days.)
A:Encapsulated bacteria (including inulin) and maltodextrin, orally taken for 16 days (from 6 days before the operation
Sponsors
Biological Research Institute of Shanghai Jiaotong University
Eligibility
Sex/Gender
All
Age
25 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 25-75 years; 2. The diagnosis is confirmed by biopsy and histologically spontaneous; 3. Undergo radical resection and no far away metastasis (including liver et al).
Exclusion criteria
Exclusion criteria: 1. Pregnancy, known lactose intolerance, clinically significant immunodeficiency, usage of antibiotics and additional gastrointestinal disorders (e.g. Crohn's disease or ulcerative colitis); 2. Patients who have received antibiotics for the last 10 days before surgery or if there is evidence of infection are excluded. Patients undergoing emergency operation are not included; 3. Patients randomized to group 2 are excluded if they have bowel preparation for colonoscopy within 6 days prior to surgery; 4. Patients undergoing proctectomy with low rectal anastomosis or surgery for polypoid lesion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma I-FABP;Bacterial translocation in MLN;Intestinal permeability;Redistribution and fluorescence of TJ proteins;Postoperative infection complication; | — |
Secondary
| Measure | Time frame |
|---|---|
| DNA fingerprint of microflora and bacterial in blood;Microflora and bacterial DNA fingerprint in feces;colonic mucosa permeability; | — |
Countries
China
Contacts
Public ContactHuanlong Qin
Outcome results
None listed