Oral cancer
Conditions
Interventions
Group A:Selective arterial cannula rAd-p53: 1*10^12/site/time, 4 days one time, total 10 times
selection of chemotherapy drug depends on the type of cancer, two days latter of the gene therapy
8 days a cycle, total two cycles
7 days stop between two cycles
Group B:Selective arterial cannula rAd-p53: 1*10^12/side/time
4 days a time
total 10 times.
Group C:Selection of chemotherapy drugs will be made according to the cancer type
the treatment to be started after two days of gene therapy
8 days a cycle, total two cycles, 7 days stop between two cycles.
Sponsors
West China Stomatology Hospital, Sichuan University
Eligibility
Sex/Gender
Male
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The patients with oral cancer to be III, IV stage (WHO 2005 version);2. Not received any treatment previously;3. 18~80 years old;4. Expected survival =6 months;5. ECOG scores 0~1;6. WBC=3.5×109/L, neutrophilic granulocyte =2.0×109/L,PLT=100.0×109/L,HGb=90g/L;7. Normal liver function include bilirubin, ?-GT, ALP and LDH; SGOT and SGPT no higher than 2.5 times of normal value;8. Renal function: creatinine concentration no higher than 1.25 times of normal value;9. Heart function 0-2 scale;10. Signed the formal consent.
Exclusion criteria
Exclusion criteria: 1. Complicated with severe systematic diseases, such as cardiovascular diseases, uncontrolled infectious diseases, systematic immune deficiency, etc.; 2. To be treated by radiotherapy, chemotherapy, surgery or other remedies; 3. Any reason will lead to unable to complete the systematic therapy; 4. To be poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| P53, Bax and bcl-2 expression;Clinical efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Antibody concentration; | — |
Contacts
Public ContactLongjiang Li
Outcome results
None listed