Protamine dose after cardiopulmonary bypass based on heparin-protamine titration

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-09000380

Enrollment

Unknown

Registered

2009-04-18

Start date

2009-04-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

rheumatic heart disease

Interventions

Group A:protamine dose based on heparin-protamine titration

Group B:protamine dose based on the heparin dose given before cardiopulmonary bypass (protamine:heparin=1mg:1mg)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: patients need to receive the valve(s) replacement enrolled in West China Hospital from April to June, 2009

Exclusion criteria

Exclusion criteria: 1. Coagulation disorders: history, such as gum bleeding and rhinorrhagia easily, menorrhagia, ecchymoses or purpura after slightly crash, coagulation diseases; PT is at least 3s longer than normal control; APPT is at least 10s longer than normal control; TT is at least 3s longer than normal control; PLt110ummol/L; 4. not first time cardiac surgery, emergency surgery, history of cerebrovacular accident; 5. surgical postoperation bleeding, surgeons dicide the protamin dose disobeying the experiment design.

Design outcomes

Primary

Measure	Time frame
1, 2, 3, 4h and 24h postoperation bleeding dose;postoperation transfusion dose;	—

Countries

China

Contacts

Public ContactDu Lei

dulei1972@yahoo.com.cn+86 028 81820399

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026