polycystic ovarian syndrome
Conditions
Interventions
Berberine Group:Berberine and Letrozole Placebo
Letrozole Group:Letrozole and Berberine Placebo
Berberine and Letrozole Group:Berberine and Letrozole
Sponsors
Affiliated Hospital Heilongjiang University of Chinese Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Age between 20 and 40 years; 2. Confirmed diagnosis of PCOS according to the Rotterdam 2003 criteria (2 of 3): (1) Oligo-ovulation or anovulation; (2) Clinical and/or biochemical signs of hyperandrogenism; (3) PCOs and exclusion of other aetiologies (congenital adrenal hyperplasia, androgen-secreting tumours and Cushing's syndrome). 3. At least one patent tube and normal uterine cavity shown by hysterosalpingogram, hysterosalpingo-contrast sonography or diagnostic laparoscopy within 3 years; 4. Sperm concentration 15*10^6/mL and progressive motility (grades a* and b**) >=40%. *Grade a: rapid progressive motility (sperm moving swiftly, usually in a straight line). **Grade b: slow or sluggish progressive motility (sperm may be less linear in their progression); 5. History of 1 year of infertility.
Exclusion criteria
Exclusion criteria: 1. Patients with known severe organ dysfunction or mental illness; 2. Use of hormonal drugs or other medications including Chinese herbal prescriptions in the past 3 months; 3. Pregnancy, postabortion or postpartum within the past 6 weeks; 4. Breastfeeding within the past 6 months; 5. Not willing to give written consent for the study.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Ovulation rate;Ongoing pregnancy rate;Multiple pregnancy rates;Miscarriage rate;Other pregnancy complications;Follicle-stimulating hormone (FSH);Luteinising hormone (LH);Total testosterone (T);sex hormone-binding globulin;Fasting glucose;Fasting insulin concentrations;cholesterol;triglycerides;high-density lipoprotein cholesterol (HDL-C);low-density lipoprotein cholesterol (LDL-C); | — |
Primary
| Measure | Time frame |
|---|---|
| live birth Rate; | — |
Countries
China
Contacts
Public ContactWu Xiaoke
Outcome results
None listed