Acute lung injury
Conditions
Interventions
A:PFC inhalation + NIPPV
B:Routine NIPPV
Sponsors
Ethic Committee of the General Hospital of the People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 65 years; 2. With the definite risk factors for acute lung injury; 3. Acute onset of ALI; 4. 200mmHg =30/min, and/or respiratory distress; 8. With indications for NIPPV juded by physicians.
Exclusion criteria
Exclusion criteria: 1. PaCO2 >50mmHg; 2. Patients should be treated with invasive ventilation through tracheal intubation or tracheotomy; 3. With difficulty in sputum coughing-up; 4. After cardiopulmonary resuscitation; 5. Severe arrhythmia or myocardial ischemia; 6. With injuries of upper airway or maxillofacial region; 7. Pneumothorax or mediastinal emphysema; 8. Severe organ insufficiency (Marshall’s scale >=3) ; 9. Obvious abdominal distension; 10. Patients that refuse the therapy by NIPPV; 11. Pregnant or breast-feeding women; 12. End stage patients (expected life span < 6 months); 13. With other conditions that prohibit the therapy determined by physicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The length, cost and mortality of ICU staying;Arterial Blood gas Analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of tracheal intubation treatment;Respiratory mechanics dynamic parameters;The rate of tracheal intubation requirement; | — |
Countries
China
Contacts
Public ContactLiang’an Chen
Outcome results
None listed