hypertension
Conditions
Interventions
Group A:The participants will be provided with a supply of normal salt from market to be used in cooking and at the table.
Group B:The participants will be provided with a supply of table salt containing equal amounts by weight of NaCl and KCl to be used in cooking and at the table.
Group C:The participants will be provided with education materials and with appropriate items to reduce their NaCl intake to 6g NaCl/day.
Sponsors
Fuwai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Older than 18 year; 2. Families with an estimated salt intake> 200 mmol/d with 50% of the salt added in the cooking or at the table) This will be estimated through an interview with the participant; 3. Willingness to participant all aspects of the study; 4. Families have no plans to leave the region in the next two years; 5. Patients with hypertension treated or untreated are eligible to participate.
Exclusion criteria
Exclusion criteria: 1. Presence of chronic renal disease with renal impairment. for instance: nephritis, nephrotic syndrome, Renal dysfunction, nephrolith, Renal cysts; 2. Plasma Creatinine > 1.7 mg/dL or eGFR 4.5 mmol/l at start or > 5.0 mmol/l at end of 1 month run in; 4. Treatment with potassium retaining drugs; 5. Chronic medication with NSAID excluding low dose aspirin; 6. Malignancy during the past 5 years; 7. Any other serious life-threatening illness that required regular medical treatment; 8. Psychiatric disease; 9. For women, current pregnancy or intent to become pregnant during the study; 10. Plans to move out of the study area, such that it would be difficult to come to the study site; 11. Seldom eat at home because of busy work; 12. Inability to cooperate, as assessed by the clinic staff.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure, urine Na and K concentration, microalbuminuria, plasma renin activity, plasma aldost; | — |
Countries
China
Contacts
Public ContactLisheng Liu, Dongfeng Gu
Outcome results
None listed