unresectable HBV-related HCC
Conditions
Interventions
Group B:without any anti-virus therapy
Group A:Anti-HBV-virus therapy
Sponsors
Shanghai Eastern Hepatobiliary Surgery Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Identify patients with HCC in accordance with the clinical diagnostic criteria of HCC passed at the Chinese Eighth National Live Cancer Academic Conference. Patients with HCC shall be diagnosed with or without pathology. It is not appropriate to perform liver resection operation; 2. serum positive HBsAg >=6 months; 3. Criteria of liver function: Child A or B level, serum total bilirubin =8.5g/dl, PT-INR6 seconds of normal value; 5. No dysfunction in major organs; Blood routine, kidney function, cardiac function and lung function are basically normal; 6. Patients who can understand this trial, male or female, aged 18-70 voluntarily participate in clinical trials and have signed information consent.
Exclusion criteria
Exclusion criteria: 1. Patients with apparent cardiac, pulmonary, cerebric and renal dysfunction, which may affect the treatment of liver cancer. 2. Patients with other diseases which may affect the treatment mentioned here. 3. Patients with medical history of other malignant tumours. 4. Subjects participating in other clinical trials. 5. Women in pregnancy and breast-feeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical symptom, laboratory examination (HBV-M, HBV-DNA, AFP, liver function), quality of life; | — |
Secondary
| Measure | Time frame |
|---|---|
| time of tumor progress(TTP), overall survival rate(OS); | — |
Countries
China
Contacts
Public ContactHu Heping
Outcome results
None listed