Head and neck cancer exclude nasopharyngeal carcinoma
Conditions
Interventions
Experimental group:Endostatin combined concurrent radiochemotherapy
Sponsors
Sun Yat-Sen University Cancer Center
Eligibility
Sex/Gender
Male
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18~60 years old; 2.KPS>=70; 3. If the patient has receipted other chemotherapy, he or she can only be treated after 30 days; 4.Clinical staging system is based on AJCC cancer staging manual, 6th Edition, 2002; 5.There is no dysfunction of heart,lung,liver and kidney; 6.Pathological classification of Malignant Epithelial tumor certified by pathological department of Sun Yat-Sen University Cancer Center; 7.Has had head and neck MRI/CT before the treatment; 8. Sign the known agreement of his/her own accord.
Exclusion criteria
Exclusion criteria: 1. Allegic to the drug of research; 2. Tumor can not be evaluated; 3. Distant metastasis; 4. Moderate anemia or more severe; 5. Have purulent or chronic infected wound which exist persistently, and severe infected; 6. Mental disease not under control; 7. Recurrence in 1 year after receipted chemotherapy with platinum; 8. Have had chemotherapy, raidotherapy, biotherapy or other treatment in 30 days; 9. Pregnancy, breast-feeding and non-reproductive; 10. Researchers believe that those who do not fit.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical benefit rate, CBR;Response rate, RR;Overall survival of 3 years;Toxicity and its reversability;Overall survival of 5 years;Overall survival, O; | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease free survival, DFS;Quality of life, QOL;Progression-free survival, PFS;Time to progression, TTP; | — |
Countries
China
Contacts
Public ContactJiang Wenqi
Outcome results
None listed