Atrial Fibrillation (AF)
Conditions
Interventions
Group A:CARTO or NavX used for left atrial geometry construction. Pulmonary vein encirclement and electrical isolation with additional roof and isthmus ablation lines. Cardioversion is used to restore
Group B:Ensite array be used for anatomical navigation and activation mapping. Incremental stimulation used to induce AF if it is not present. Stepwise linear ablation guiding by non contact mapping a
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Paroxysmal atrial fibrillation: Symptomatic AF refractory or intolerant to at least 2 antiarrhythmic medication; 2. Persistent atrial fibrillation: AF history >6 months or AF recurrent within 1 week after effective pharmacologic or electrical cardio version.
Exclusion criteria
Exclusion criteria: 1. Contraindication to amiodarone therapy or anticoagulation with warfarin; 2. Left atrial diameter >55 mm; 3. Left ventricular ejection fraction <35 percent; 4. Presence of left atrial thrombus on transesophageal echocardiography or CT or MRI; 5. Structural heart disease: Unstable angina, acute or prior myocardial infarction, uncontrolled systemic hypertension, nonischemic cardiomyopathy, uncorrected valvular disease or presence of a mechanical prosthetic valve; 6. History of a cerebrovascular accident; 7. AF secondary to transient or correctable abnormality (hyperthyroidism, alcoholism and drug intoxication etc); 8. Prior attempt at catheter or surgical ablation for atrial fibrillation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Freedom from Atrial fibrillation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complications, left atrium diameter, left ventricular ejection fraction and severity of symptoms; | — |
Countries
China
Contacts
Public ContactAnli Tang
Outcome results
None listed