Hepatocellular carcinoma
Conditions
Interventions
Group A:hypodermic injection LMWH 4100 IU each 12 hours in 6 weeks
TACE scheme: iodine oil 1.5ml/cm diametre tumour, Epirubicin Hydrochloride injection 20mg, 5-Fu 1g, Carboplatin 150 mg.
Sponsors
Shanghai Eastern Hepatobiliary Surgery Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Adults patients with a diagnosis of HCC which is not amenable to surgical resection, liver transplantation or local ablative therapy; Without metastasis out of liver Patients must have at least one tumor lesion that meets both of the following criteria:The lesion can be accurately measured in at least one dimension according to RECIST criteria The lesion has not been previously treated with surgery, radiation therapy, radiofrequency ablation, percutaneous ethanol or acetic acid injection, or cryoablation. ECOG performance status (PS) <2 No prior targeted antiangiogenic therapy. Metronomic chemotherapies are allowed. At least 4 weeks since prior systemic chemotherapy Child-Pugh class A or B No significant renal impairment (creatinine clearance < 30 mL/minute) or patients on dialysis Ability to understand the protocol and to agree to and sign a written informed consent document
Exclusion criteria
Exclusion criteria: HBSAg(-), AFP(-). prothrombin time prolonged more than 4s. blood platelets count less than 50000/L. Renal failure requiring dialysis. Child-Pugh class C hepatic impairment. clinically significant gastrointestinal bleeding within 30 days prior to study entry. History of organ allograft. Substance abuse (current), psychological, or social conditions that may interfere with the patient's participation in the study or evaluation of the study results. Known or suspected allergy to the investigational agents or any agent given in association with this trial. Pregnant or breast-feeding patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival time;Survival time with no progress of tumour; | — |
Secondary
| Measure | Time frame |
|---|---|
| Response rate; | — |
Countries
China
Contacts
Public ContactJiamei Yang
Outcome results
None listed