Moderate or major abdominal surgery.
Conditions
Interventions
Experimental group:SMOFlipid 20%
Control group:SMOFlipid 20%
Sponsors
Nanjing General Hospital of Nanjing Military Command of Chinese PLA
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Moderate or major abdominal surgery; patients to be treated with post-operative total parenteral nutrition over 5 days at least; 18-80 years old; patients has given his/her written informed consent.
Exclusion criteria
Exclusion criteria: Severe hyperlipidemia(plasma triglycerieds and/or cholesterol and/or LDL-C > 50% above the upper limit of normal range); type 1 diabetes mellitus and/or severe type 2 diabetes mellitus;metabolic diseases (hyperthyroidism/hypothyroidism, adrenal cortex disorders); BMI30 {BMI=Weight (Kg)/[Height (m) x height (m)]}; severe renal insufficiency(creatinine more than 200% above the upper limit of the normal ranges); severe liver insufficiency (AST and/or ALT and/or bilirubin more than 200% above the upper limit of the normal ranges);severe blood coagulation disorders; any condition of decompensated acute or chronic heart insufficiency;severe diseases or unstable vital signs within last 48 hours; history of organ transplantation;history of drug allergy, asthma, urticaria or known allergy to fish protein, egg protein or soy protein;concomitant other nutrition therapy or medications may influence nutrition therapy (e.g. somatotropin); pregnancy or breast-feeding women; participation in other clinical trials within 4 weeks prior to the beginning of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| concentration of triglycerides, prealbumin, transf; | — |
Secondary
| Measure | Time frame |
|---|---|
| The serum levels of total cholesterol, total prote;Blood free fatty acid spectrum;LTB5 / LTB4, TXB3 / TXB2 ratio;IL-1, IL-2, IL-6 and CD4 / CD8 and HLA-DR level; | — |
Countries
China
Contacts
Public ContactLi Ning
Outcome results
None listed