small cell lung cancer
Conditions
Interventions
Group 1:IP scheme for four cycles.
Group 2:EP scheme for four cycles
Sponsors
Henan Province Tumour Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients with SCLC confirmed by cytology or histology; 2.be widespread stage of VALG; 3.never received any chemotherapy; 4. at least has a testable tumour by two ways diameters, and >=20mm scanned by general CT or MRI, or >=10mm by screw CT; 5. ECOG PS scores 0-2; 6.Aged 18-70; 7. be expected survival more than 3 months; 8.no dysfunction of main organ: WBC>=4.0*10^9/L, neutrophilic granulocyte>=2.0*10^9/L, platelet>=100*10^9/L, Hb>=95g/L; (1) Liver function: serum bilirubin less than the maximum normal value 1.5 folders; ALT and AST less than the maximum normal value 1.5 folders; (2) Renal function: creatinine clearance rate >=45mL/min; (3) Heart function: normal.
Exclusion criteria
Exclusion criteria: 1. with uncontrolled metastasis tumour in central nerve system; 2. with uncontrolled hypertension, unstable angina, MI history, or congestive heart-failure, uncontrolled arrhythmia, ischemic mucosa disease, ischemic heart condition, cardiac valve, peripheral neuropathy, infectious diseases, pregnancy or breed feeding woman, uncontrolled mental illness; 3. weight loss >=10% in last six weeks; 4. unable to stop the use of steroids drugs; 5. suffered other active tumours except non melanoma skin cancer, original cervical carcinoma and recovered early prostatic csarcinoma; 6. poor compliance; 7. others the trialist considered not suitable for attending the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time of tumour progress (TTP);Survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| tolerance and safety;Morbidity of other diseases;Quality of life;Efficient (ORR);Disease control rates (DCR); | — |
Countries
China
Contacts
Public ContactZhiyong Ma
Outcome results
None listed