Ib~IIa Cervical Cancer
Conditions
Interventions
Radiotherapy:External irradiation 50Gy/5 weeks Lateral: 2 cm lateral to the bony margin of the pelvis Superior: Between L5 and S1 Inferior: 2 cm below the obturator foramen Intracavitary boost 30-35Gy
Concurrent chemoradiation:External beam radiation with concurrent weekly platinum chemotherapy
Sequence chemotherapy and radiotherapy:2 cycles chemotherapy of Paclitaxel and Cisplatin before and after the irradiation
Sponsors
Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with newly histologically confirmed cervical carcinoma Original clinical stage must be Ib~IIa (FIGO) Age between 18-65 With the presence of these four factors after radical surgery: (1) positive lymph nodes; (2) positive parametria, or positive surgical margins; (3) positive lymphatic vascular space; (4) outer one-third invasion of the cervical stroma. More than 3 months survival is to expect Patients must give signed informed consent.
Exclusion criteria
Exclusion criteria: The presence of uncontrolled life-threatening illness; Receiving other ways of anti-cancer therapy; Residual tumor which can not be removed in the surgery; Investigator consider the patients can't finish the whole study; With normal liver function test (ALT, AST>2.5*ULN); With normal renal function test (Creatinine>1.5*ULN); WBC<4,000/mm3 or PLT<100,000/mm3; Receive the external pelvic irradiation before the surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival, 5-year survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| distant metastasis free survival,disease free survival; | — |
Countries
China
Contacts
Public ContactJihong Liu
Outcome results
None listed