STEMI
Conditions
Interventions
RLD:routine loading dose clopidogreal (300 mg)
HLD:high loading dose clopidogreal (600 mg)
Sponsors
Department Of Cardiology, Shanghai Renji Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Criteria for study entry were age over 18 years; ischemic type chest pain of > 30 min duration; ST-segment elevation in at least 2 contiguous ECG leads with the cut-off points =0.2 mV in leads V1, V2 or V3 and =0.1 mV in other leads; admission to hospital within 12 h of the onset of symptoms.
Exclusion criteria
Exclusion criteria: infarction; previous coronary artery bypass grafting; a culprit lesion in the left main coronary artery, distal artery or small branch; contraindication to clopidogrel; administration of clopidogrel prior to randomization; use of anticoagulants within 10 days with an INR > 1.5; active bleeding or significant risk of bleeding; severe liver, renal, or brain dysfunction; life-limiting noncardiac disease (e.g., advanced cancer, end-stage pulmonary disease); suspected aortic dissection; and pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resolution of ST-segment elevation on ECG;WMSI in Echocardiography;Ventricular remodelling in Echocardiography;Thrombolysis In Myocardial Infarction (TIMI) trial;The TIMI myocardial perfusion grade (TMPG);The corrected TIMI frame count(CTFC);Cardiac marker enzymes;Major adverse cardiac events (MACE); | — |
Countries
China
Contacts
Public ContactBen He, Jun Pu
Outcome results
None listed