Alzheimer disease
Conditions
Interventions
S group:Continuous spinal anesthesia only. Collecting CSF 1-1.5ml before and 2 hours after anesthesia respectively.
SI group:After continuous spinal anesthesia is stable, we inject propofol 2mg/kg, then insert LMA and make 1-1.5MAC isoflurane inhaled 2 hours continuously to maintain BIS between 50-60, remaining spo
SP group:After continuous spinal anesthesia is stable, inject propofol 2mg/kg, then insert LMA and infuse propofol 2 hours continuously to maintain BIS between 50-60, remaining spontaneously breathing
SD group:After continuous spinal anesthesia is stable, inject propofol 2mg/kg, then insert LMA and make 1-1.5MAC desflurane inhaled 2 hours continuously to maintain BIS between 50-60, remaining sponta
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients aged from 65-75 years old and schedule to undergo lower limb or hypogastrium operation; ASA I-II; without mental or neurologic disease;educated; no disorder in auditus, vision and language. And all patients accept continuous spinal anesthesia.
Exclusion criteria
Exclusion criteria: Patients will be excluded when (1) They are over 75 yrs or below 65 yrs; (2) They can't accept continuous spinal anesthesia; (3) They have mental or neurologic disease; (4) ASA III or higher; (5) They have contraindication to relative drug; (6) They have anxiety-depression or severe complication after operation; (7)They are taking part in other trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A beta 40 and A beta 42 in CS; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-1beta, TNF-alpha, S100 beta, NSE in CS; | — |
Countries
China
Contacts
Public ContactBin Zhang
Outcome results
None listed