In vitro effects of alpha 1-blockers on human seminal vesicles: relevance to ejaculation dysfunction

The effects of alpha 1-blockers and alpha 1-adrenoceptor subtypes on human ejaculation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-08000186

Enrollment

Unknown

Registered

2008-11-11

Start date

2007-05-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

the ejaculation dysfunction caused by alpha 1-blockers

Interventions

Group 1:The effects of tamsulosin (1nM and 10nM) the strips in response to cumulatively increasing concentrations of noradrenaline (1-1000uM) were evaluated.

Group 2:The effects of prazosin (10nM and 30nM) the strips in response to cumulatively increasing concentrations of noradrenaline (1-1000uM) were evaluated.

Group 3:The effects of terazosin (100nM and 300nM) the strips in response to cumulatively increasing concentrations of noradrenaline (1-1000uM) were also evaluated.

Group 4:The effects of naftopidilon (300nM and 1000nM) the strips in response to cumulatively increasing concentrations of noradrenaline (1-1000uM) were also evaluated.

Eligibility

Sex/Gender

Male

Age

55 Years to 75 Years

Inclusion criteria

Inclusion criteria: Human seminal vesicles were obtained from patients undergoing radical cystectomy and prostatectomy.

Exclusion criteria

Exclusion criteria: 1. Preoperatively, all patients were never under therapy interfering with seminal vesicles function; 2. no tumor invasion in smooth muscle strips of seminal vesicles

Design outcomes

Primary

Measure	Time frame
the frequency of contraction;contraction amplitude;	—

Countries

China

Contacts

Public ContactHong Li

wzwzl@yahoo.com.cn+86 028 81812848

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026