Prospective randomized control trial of splenectomy and portal-azygous disconnection in the treatment of hepatocellular carcinoma complicated with portal hypertension

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-08000154

Enrollment

Unknown

Registered

2008-09-23

Start date

2009-01-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma

Interventions

Experiment group:Radical hepatectomy, splenectomy and portal-azygou

Control group:Radical hepatectomy only

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age 20-65years and pimary organs (heart, brain and lungs) are tolerant to the syrgery; 2. Single tumor and diameter <=5cm; 3. Cirrhosis after HBV infectionand complicated with splenomegaly or hypersplenism; 4. Moderate-serious esophageal or gastric fundal varices detected by gastroscopy; 5. Liver function grade: Child-Pugh A; 6. Participants attend the trial of their own free will and sign the informed consent form before operation.

Exclusion criteria

Exclusion criteria: 1. Complicated with HCV or alcoholic cirrhosis; 2. Multiple tumors or diameter >5cm; 3. No and mild esophageal or gastric fundal varices; 4. Liver function grade: Child-Pugh B or C; 5. Non-primary liver cancer or diameter<1.0cm in postoperative pathology.

Design outcomes

Primary

Measure	Time frame
Incidence rate of perioperative complication;Incidence rate of upper digestive tract hemorrhage;Mortality rate of upper digestive tract hemorrhage;perioperative mortality rate;Postoperative long-term survival rate;	—

Countries

China

Contacts

Public ContactTian Yang

yangtian6666@hotmail.com+86 13321955805

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026