Drug combination of clinical anesthesia
Conditions
Interventions
Lidocaine Group:(1) i.v. scopolamine 0.3 mg as premedication 20 min before induction, at the beginning of fluid infusion.
Control Group:(1) i.v. scopolamine 0.3 mg as premedication 20 min before induction, at the beginning of fluid infusion
Sponsors
Capital Medical University affiliated Beijing Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients aged from 18-65 years old and schedule to undergo thoracic surgery lasting 3-6 h will be enrolled in this study. All need to have American Society of Anesthesiologists (ASA) physical status I-II.
Exclusion criteria
Exclusion criteria: Patients will be excluded from the study when (1) they have chronic pain state; (2) they take analgesics or have used opioids within 7 day before surgery; (3) they have a history of drug or alcohol abuse, psychiatric disorder, or obesity (>130% of ideal body weight); (4) they have acute cardiovascular disorder, or unstable hypertension; (5) they have central nervous system diseases; (6) they can’t communicate with investigator; (7) they have contraindications to propofol, opioids and lidocaine; (8) they have contraindications to the self- administration of morphine [i.e., unable to understand the patient-controlled analgesia (PCA) device]; (9) their surgery lasting more than 6 h; or (10) their immediate extubation is not planned after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain electrica; | — |
Countries
China
Contacts
Public ContactYanping Li
Outcome results
None listed