volunteers
Conditions
Interventions
RT group:subcutaneously injected reference preparation rhGM-CSF150 ug in the first cycle, after one week orally administered rhGM-CSF 480 ug in the scond cycle
TR group:orally administered rhGM-CSF 480 ug in the first cycle, after one week subcutaneously injected reference preparation rhGM-CSF150 ug in the scond cycle
Sponsors
Insititute of Biochemistry, College of Life Science, Zhejiang Sci-Tech University
Eligibility
Sex/Gender
Male
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. healthy male subjects; 2. the age of 18 to 40-year-old; 3. weight over 50 kg, body mass index [BMI = weight (kg) / height (m) 2] at 19 ~ 25 kg/m2 range; 4. no history of organ diseases and history of drug allergy; 5. non-drug abusers; 6. non-alcoholic drinks and tobacco habits; 7. no-taking drug treatment within the past two weeks; 8. with good communication between researchers, to comply with the requirements of the entire study; 9. signed informed consent.
Exclusion criteria
Exclusion criteria: 1. participated other clinical trials in last 2 months; 2. donated blood during the trial period or within last 1 month; 3. did not accept physical examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rhGM-CSF concentration in blood plasma; | — |
Countries
China
Contacts
Public ContactYaozhou Zhang
Outcome results
None listed