Acute Myeloid Leukemia
Conditions
Interventions
Fludarabine+Cytarabine+G-CSF(FLAG):Fludarabine 30mg/m^2/d d1-5
Cytarabine 1.5g/m^2/d
Fludarabine+Cytarabine (FA):Fludarabine 30mg/m^2/d d1-5
Sponsors
Changhai Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 60 Years
Inclusion criteria
Inclusion criteria: The diagnosis is consistant with the FAB criteria for acute myeloid leukemia (not acute promyelocytic leukemia). The criteria for relapsed and refractory leukemia is referred to The 6th National Leukemia Conference (1991). Refractory leukemia is defined as 1. The newly diagnosed patient did not achieve complete remission after two cycles of standard regimen (HA and DA) ; 2. After complete remission, the first relapse occurred within 6 months during consolidation; or relapse after 6 month, but refractory to standard therpy; 3. multiple replased patients.
Exclusion criteria
Exclusion criteria: 1. Cardiac dysfunction, >grade II; 2.Renal or liver dysfunction, serum direct bilirubin, indirect bilirubine, ALT, AST, serum creatinine more than 1.25 times institutional upper limits of normal; 3.Female patients in labor; 4.Comboridity with other malignancies; 5.Combordity with severe infectious or metabolic disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete remission rate;Partial remission rate;Security Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| median duration of complete remission; | — |
Contacts
Public ContactJianmin Wang
Outcome results
None listed