Advanced cervical carcinoma
Conditions
Interventions
RT:the conventional fractionation 2Gy/day, five fractions a week, with a total dose of 70-80Gy was given to the primary tumor
GTRT:In the GTRT group, Gendicine 1*10^12 virus particle (vp) was intratumorally injected once a week for six weeks and concurrently irradiation was given. the conventional fractionation 2Gy/day, five
Sponsors
Beijing Cancer Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients should be 18 to 80 years old. All patients were staged as unresectable IIB, III, or IVA according PICO staging system. Initial treatment with radiotherapy was judged to be the accepted standard of care. Patients must have a projected life expectancy of at least 6 months and a Karnofsky performance score of at least 70%. Patients were required to have adequate bone marrow function (WBC count 4.0*10^9/L, hemoglobin 7g/L, platelet count 70*10^9/L) and adequate liver and renal function (AST, ALT, BUN and Cr <1.5 time the upper limit of normal).
Exclusion criteria
Exclusion criteria: Pregnant or nursing women, patients with uncontrolled serious infections, or with serious heart and lung failure were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Local-regional recurrence;Survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor response; | — |
Countries
China
Contacts
Public ContactZhang Shanwen
Outcome results
None listed