STEMI
Conditions
Interventions
Saline Group:Intracoronary Saline
Verapamil Group:Intracoronary Verapamil
BNP Group:Intracoronary rhBNP
Sponsors
Department Of Cardiology, Shanghai Renji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Criteria for study entry were age over 18 years; ischemic type chest pain of > 30 min duration; ST-segment elevation in at least 2 contiguous ECG leads with the cut-off points =0.2 mV in leads V1, V2 or V3 and =0.1 mV in other leads; admission to hospital within 12 h of the onset of symptoms.
Exclusion criteria
Exclusion criteria: Exclusion criteria were systolic blood pressure <90 mm Hg (including cardiogenic shock) or requirement for mechanical support (intra-aortic balloon pumping, mechanical ventilation, or both); a history of myocardial infarction; previous coronary artery bypass grafting; a culprit lesion in the left main coronary artery, distal artery or small branch; rescue intervention after failed thrombolysis; a known allergic reaction to rhBNP; severe liver, renal, or brain dysfunction; life-limiting noncardiac disease (e.g., advanced cancer, end-stage pulmonary disease); suspected aortic dissection; and pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WMSI in Echocardiography;The TIMI myocardial perfusion grade (TMPG); | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurohormonal factors (Aldosterone);angiotensin II, aldosterone, ET-1, norepinephrine,;Resolution of ST-segment elevation on ECG;Major adverse cardiac events (MACE);The corrected TIMI frame count(CTFC);Ventricular remodelling in Echocardiography;Thrombolysis In Myocardial Infarction (TIMI) trial; | — |
Countries
China
Contacts
Public ContactBen HE; Jun PU
Outcome results
None listed