Post-respiratory syncytial virus bronchiolitis wheezing
Conditions
Interventions
1:Azithromycin for three days
2:placebo
Sponsors
Department of Paediatrics, The Chinese University of Hong Kong
Eligibility
Sex/Gender
Male
Age
1 Years to 1 Years
Inclusion criteria
Inclusion criteria: 1. previously well infants less than or equal to 12 months of age; 2. first episode of wheezing requiring hospitalization, and with a clinical diagnosis of bronchiolitis. Bronchiolitis is diagnosed based on clinical findings including wheezing or wheezing with crackles preceded by upper respiratory tract infection symptoms, and respiratory distress with retractions; 3. admitted in hospital for 24 hours; 4. laboratory confirmed presence of RSV in nasopharyngeal aspirate, and 5. signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. infants with any cardio-respiratory illness, immunodeficiency or were born prematurely (gestational age <37 weeks); 2. infants who had received corticosteroids within 24 hours before presentation; 3. infants who had received antibiotic treatment less than seven days before hospital admission, and 4. infants requiring mechanical ventilation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the number of wheezing attacks in the following 12 months after the initial illness.; | — |
Secondary
| Measure | Time frame |
|---|---|
| length of hospital stay (LOS) (in hours) defined as the time between study entry;the actual time that the subject is declared fit for discharge.; | — |
Countries
China
Contacts
Public ContactAlbert Martin LI
Outcome results
None listed