COPD (moderate stable stage)
Conditions
Interventions
Group A:Tiotropium bromide 18ug inhalation Qd + Placebo 0.2 g oral B.i.d.
Group B:Tiotropium bromide 18ug inhalation Qd + sustained-release theophyline 0.2 oral-taking Bid
Sponsors
The First Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients with the diagnosis of moderate stable COPD (according to the diagnosis and treatment guidelines for COPD established by Chinese Medical Association in 2007) and presentation of dyspnea.
Exclusion criteria
Exclusion criteria: 1. With other disease that may cause airflow obstruction (bronchial asthma, bronchiestasis, pulmonary tuberculosis, diffuse panbronchiolitis, et al); 2. Respiratory tract infection within 2 weeks and in 2 weeks of washout; 3. Allergic to anticholinergic agents, theosine, lactose, et al; 4. Narrow angle glaucoma; 5. Hyperplasia of prostate gland with obvious symptoms; 6. Bladder orifice stricture; 7. Long-term use of glucocorticoids, long-actingß-adrenergic receptor agonists, leukotriene antagonists, antihistamine drugs and antibiotics; 8. Dysfunction of heart, liver, kidney or lung; 9. Pregnant or breast-feeding women; or women of childbearing age without contraception; 10. History of alcohol, drugs and drugs addiction or other factors influencing the compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of life;Side effects;Lung function; | — |
Countries
China
Contacts
Public ContactHongmei Yue
Outcome results
None listed