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A Randomized Controlled Trial to Compare the Safety and Efficacy of Intravitreal Triamcinolone Versus Combined Triamcinolone and Grid Laser Versus Observation in the Treatment of Macular Edema Associated With Central Retinal Vein Occlusion

A Randomized Controlled Trial to Compare the Safety and Efficacy of Intravitreal Triamcinolone Versus Combined Triamcinolone and Grid Laser Versus Observation in the Treatment of Macular Edema Associated With Central Retinal Vein Occlusion

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-TRC-05000661
Enrollment
Unknown
Registered
2005-09-21
Start date
2005-01-15
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eye Diseases

Interventions

Twp groups:Treatment of macular edema secondary to CRVO with ivTA without laser 30 months

Sponsors

Nil
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. Age of at least 18 years; 2. Visual acuity 20/50 or poorer; 3. Macular edema of at least 250µm involving the fovea, as documented on optical coherent tomogram; 4. Patients with best corrected visual acuity of better than 1.7 ETDRS logMar units; 5. Patients physically fit to receive laser photocoagulation or intravitreal injection; 6. Informed consent.

Exclusion criteria

Exclusion criteria: Exclusion criteria 1. Previous photocoagulation for retinal vascular disease of study eye; 2. Intercurrent eye disease except cataract and refractive error that is likely to affect visual acuity over study period; 3. Glaucoma and history of ocular hypertension; 4. Presence of peripheral anterior synechia in the study case; 5. Media opacities which affect fundus examination or OCT measurements; 6. Previous intraocular surgery except uncomplicated cataract extraction and posterior intraocular lens insertion; 7. Any cataract extraction or laser procedure within 3 months; 8. Pregnant patients; 9. Failure to comply with follow up schedule

Design outcomes

Primary

MeasureTime frame
Best-corrected visual acuity (ETDRS chart);

Secondary

MeasureTime frame
1. Macular edema 2. Intraocular pressure 3. Degree of cataract assessed clinically 4. To measure the level of vascular endothelial growth factor in the vitreous at the time of treatment;

Countries

China

Contacts

Public ContactProf. Dennis SC Lam
dennislam_cu_res@cuhk.edu.hk+852 27623134

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026