Evaluation of Nitrous oxide In the Gas Mixture for Anesthesia: a randomized controlled Trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-05000656

Enrollment

Unknown

Registered

2005-09-13

Start date

2004-01-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Interventions

Two groups:Nitrous oxide in intraoperative peroid versus Nitrous oxide administration

Eligibility

Sex/Gender

Male

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Males and females, age 18 years and over; 2. Planned general anesthesia for surgery that includes a skin incision and expected to exceed two hours, and the patient is expected to be in hospital for at least three days.

Exclusion criteria

Exclusion criteria: Exclusion Criteria: 1. Endoscopic or radiological procedures; 2. Cardiac surgery; 3. Marked impairment of gas-exchange (requiring FiO2 > 0.3); 4. Thoracic surgery requiring one-lung ventilation (requiring FiO2 > 0.3); 5. Specific circumstances where N2O is contraindicated (eg. volvulus, pulmonary hypertension, raised intracranial pressure); 6. Lack of provision of N2O.

Design outcomes

Primary

Measure	Time frame
Length of hospital stay;	—

Secondary

Measure	Time frame
Perioperative complications Endothelial reactivity COMET assay;	—

Countries

China

Contacts

Public ContactMatthew Chan

mtvchan@cuhk.edu.hkNil

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026