retinitis pigmentosa
Conditions
Interventions
case series:autologous bone marrow mesenchymal stem cell infusion therapy
Sponsors
Southwest Hospital, Third Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patient has signed informed consent for retinal transplantation and is willing to return for follow-up visits;2. Age range 18 to 65 years,gender unlimited; 3.Patients with at least one eye (monocular) or both eyes suffering from impaired vision caused by retinitis pigmentosa; 4.Use the early treatment diabetic retinopathy (ETDRs) eye chart in 4 meters distance detection, best corrected visual acuity scores between 19 and 73 letter, including 19 and 73 (or the equivalent of about Snellen eyesight from 20/400 to 20/40).
Exclusion criteria
Exclusion criteria: 1. Patient has medical problems that have a high risk of general anesthesia, such as metabolic, cadiovascular, hematopoietic or psychological system disorders; 2. Women in menstruation, pregnancy, perinatal prtiod and baby nursing periods; 3. Any significant ocular disease that has compromised or could compromise vision in the study eye and confound analysis of the primary outcome; 4. Patient who has a history of corneal leukoma, cataract, uveitis, Coat’s disease, diabetic retinopathy, glaucoma, or vitreous opacities that prevents visualization of the posterior pole; 5. Participating in another ophthalmic clinical trial or use of any other investigational new drugs within 3 months before the start of study treatment; 6. Intraocular surgery within the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Early treatment of diabetic retinopathy eye chart(;Fluorescein angiography;Static perimetry;Optical coherent tomography(OCT);Flash electroretinogram(FERG);Flash Visual Evoked Potentials(FVEP);mutifocal electroretinogram(MFERG);Pupillary light refle; | — |
Countries
China
Contacts
Public ContactYin Zhengqin
Outcome results
None listed