Risk factors and intervention for cardiology, cerebrovascular and related disease (Kailuan Study)

Risk factors and intervention for cardiology, cerebrovascular and related disease

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-TNRC-11001489

Enrollment

Unknown

Registered

2015-07-19

Start date

2006-01-01

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CVD, Parkinson, Dementia, Renal disorders, Sleep disorders, Diabetes, Autoimmune diseases, Taste/olfactory disorder, Cancer, Liver disease and respiratory disease

Wang H, Zhang Y, Yuan J, Du X, Shao Q, Li S, Zeng M, Wu S, Yang W, Yan X.

2026-06-22

10.1097/cm9.0000000000004187

Cohort Profile: the Kailuan Study

S L Wu, X Ding, BY Feng, Wang Xm, C Jin et al. (14 authors)

Cardiac Research2026-05-28

10.1097/re9.0000000000000021

Life's Essential 8 and the Risk of Overall and Specific-Site Cancer Types: A Large-Scale Prospective Cohort Study.

Deng L, Hao XM, Shu Z, Liu T, Zhang QS, Wang HT, Shi HP.

2026-01-01

10.1002/cam4.71518

Association between onset age and mortality gradients in advanced cardiovascular–kidney–metabolic syndrome

Jin-Jin Dai, Chuanchang Wu, Shihua Liu, Shuohua Chen, Xiaodan Hong et al. (9 authors)

Frontiers in Endocrinology2025-09-03

10.3389/fendo.2025.1648083

Metabolic syndrome, high-sensitivity C-reactive protein and the risk of heart failure: the Kailuan cohort study

Yan Tian, Yanxiu Wang, Dandan Zhao, Huayu Sun, Hao Wu et al. (10 authors)

Frontiers in Endocrinology2025-04-22

10.3389/fendo.2025.1544823

Age-Dependent Associations Between Pulse Pressure and Long-Term Outcomes After Myocardial Infarction.

Miao C, Zhao D, Chen S, Xu L, Huang Y, Li H, Deng H, Wu L, Wang Y, Fu Y, Wu G, Wu S, Hong J, Yang WY.

2025-04-01

10.1111/jch.70043

Analysis of the Sex-Specific Risk Factors for Arterial Stiffness

Jinhuan Yuan, Chengwen Wang, Chong Zhao, Hua Liu, Yiwen Zhang et al. (8 authors)

Reviews in Cardiovascular Medicine2025-02-201 citations

10.31083/rcm25478

In utero and childhood exposure to the great Chinese famine and risk of aging in adulthood.

Ma T, Hao XM, Zhang X, Liu XY, Wang YM, Zhang QS, Zhang J.

2024-10-232 citations

10.1038/s41598-024-77283-z

A Comparison of Oscillometrically Measured Ankle-to-Brachial Mean Arterial Pressure Ratio and Ankle-Brachial Index in Predicting Cardiovascular Events and All-Cause Mortality.

Ji C, Wu S, Huang Z, Zhu C, Cui W.

2024-08-03

10.14744/anatoljcardiol.2024.4262

Temporal relationship between inflammation and metabolic disorders and their impact on cancer risk

Chenan Liu, Tong Liu, Qingsong Zhang, Mengmeng Song, Qí Zhāng et al. (15 authors)

Journal of Global Health2024-02-1513 citations

10.7189/jogh.14.04041

Age Differences in the Association of Sleep Duration Trajectory With Cancer Risk and Cancer-Specific Mortality: Prospective Cohort Study.

Liu C, Zhang Q, Liu C, Liu T, Song M, Zhang Q, Xie H, Lin S, Ren J, Chen Y, Zheng X, Shi J, Deng L, Shi H, Wu S.

2024-02-075 citations

10.2196/50836

Prediction of Major Adverse Cardiovascular Events by Triglyceride Glucose Index in Predominantly Male Patients with Rheumatoid Arthritis

Jiawei Zhang, Qiqi Hou, Quanle Han, Xu Peng, Hongxia Cao et al. (7 authors)

Reviews in Cardiovascular Medicine2024-01-156 citations

10.31083/j.rcm2501028

Enlarged Perivascular Spaces in Relation to Cumulative Blood Pressure Exposure and Cognitive Impairment

Huijing Shi, Liufu Cui, Ying Hui, Shouling Wu, Xiaoshuai Li et al. (15 authors)

Hypertension2023-07-2126 citations

10.1161/hypertensionaha.123.21453

Habitually Skipping Breakfast Is Associated with the Risk of Gastrointestinal Cancers: Evidence from the Kailuan Cohort Study.

Liu T, Wang Y, Wang X, Liu C, Zhang Q, Song M, Song C, Zhang Q, Shi H.

2023-03-0316 citations

10.1007/s11606-023-08094-7

The association between arterial stiffness and cancer occurrence: Data from Kailuan cohort study

Yinong Jiang, Aijun Xing, Tesfaldet H. Hidru, Jiatian Li, Xiaolei Yang et al. (8 authors)

Frontiers in Cardiovascular Medicine2023-03-017 citations

10.3389/fcvm.2023.1112047

The effect of adverse pregnancy outcomes on vascular aging in young women: the Kailuan study.

Liu Y, Lin L, Tao B, Ding X, Chen S, Wang G, Shi J, Huang Z, Yu J, Yang N, Wu S, Li Y.

2023-02-07

10.1038/s41371-023-00805-1

Estimated pulse wave velocity can predict the incidence of new-onset atrial fibrillation: A 11-year prospective study in a Chinese population

Haojia Chen, Guanzhi Chen, Liling Zhang, Weiqiang Wu, Weijian Li et al. (9 authors)

Frontiers in Cardiovascular Medicine2022-08-228 citations

10.3389/fcvm.2022.912573

Association between metabolic syndrome, C-reactive protein, and the risk of primary liver cancer: a large prospective study.

Song M, Liu T, Liu H, Zhang Q, Zhang Q, Wang Y, Ma X, Cao L, Shi H.

2022-08-048 citations

10.1186/s12885-022-09939-w

High salt intake combined with hypertension elevated the risk of primary liver cancer: a prospective cohort study.

Liu T, Zhang Q, Xiao X, Wang Y, Ma X, Song M, Zhang Q, Cao L, Shi H.

2022-08-038 citations

10.3389/fonc.2022.916583

The combination of metabolic syndrome and inflammation increased the risk of colorectal cancer.

Liu T, Fan Y, Zhang Q, Wang Y, Yao N, Song M, Zhang Q, Cao L, Song C, Shi H.

2022-06-1814 citations

10.1007/s00011-022-01597-9

C-reactive protein and atrial fibrillation: Insights from epidemiological and Mendelian randomization studies.

Li X, Peng S, Wu X, Guan B, Tse G, Chen S, Zhou G, Wei Y, Gong C, Lu X, Xu J, Wu S, Liu S.

2022-03-1526 citations

10.1016/j.numecd.2022.03.008

Association of Visit‐to‐Visit Variability in Fasting Plasma Glucose with Digestive Cancer Risk

Nan Zhang, Yueying Wang, Gary Tse, Guangping Li, Shouling Wu et al. (6 authors)

Oxidative Medicine and Cellular Longevity2022-01-017 citations

10.1155/2022/4530894

In utero and childhood exposure to the Great Chinese Famine and risk of cancer in adulthood: the Kailuan Study.

Zhang X, Wang G, Forman MR, Fu Q, Rogers CJ, Wu S, Gao X.

2021-12-0112 citations

10.1093/ajcn/nqab282

Associations between hepatitis B virus infection and risk of colorectal Cancer: a population-based prospective study.

Liu T, Li W, Zhang Y, Siyin ST, Zhang Q, Song M, Zhang K, Liu S, Shi H.

2021-10-189 citations

10.1186/s12885-021-08846-w

The risk of ischemic stroke and hemorrhagic stroke in Chinese adults with low-density lipoprotein cholesterol concentrations < 70 mg/dL

Zhijun Wu, Zhe Huang, Alice H. Lichtenstein, Yesong Liu, Shuohua Chen et al. (10 authors)

BMC Medicine2021-06-1641 citations

10.1186/s12916-021-02014-4

Cumulative burden of lipid profiles predict future incidence of ischaemic stroke and residual risk

Liye Dai, Jie Xu, Yijun Zhang, Anxin Wang, Zimo Chen et al. (10 authors)

Stroke and Vascular Neurology2021-04-0732 citations

10.1136/svn-2020-000726

A prospective follow-up study of the relationship between high-sensitivity C-reactive protein and primary liver cancer.

Siyin ST, Liu T, Li W, Yao N, Xu G, Qu J, Chen Y.

2020-11-307 citations

10.1186/s12885-020-07665-9

Risk stratification for mortality in cardiovascular disease survivors: A survival conditional inference tree analysis.

Wu Z, Huang Z, Wu Y, Jin Y, Wang Y, Zhao H, Chen S, Wu S, Gao X.

2020-10-034 citations

10.1016/j.numecd.2020.09.029

Habitual Night Eating Was Positively Associated With Progress of Arterial Stiffness in Chinese Adults.

Zhang X, Wu Y, Na M, Lichtenstein AH, Xing A, Chen S, Wu S, Gao X.

2020-09-2124 citations

10.1161/jaha.120.016455

Risk of primary liver cancer associated with gallstones and cholecystectomy: A competing risks analysis.

Liu T, Siyin ST, Yao N, Xu G, Chen YT, Duan N, Li W, Qu J, Liu S.

2020-09-017 citations

10.1097/md.0000000000022428

Metabolic syndrome, high-sensitivity C-reactive protein levels and the risk of new-onset atrial fibrillation: Results from the Kailuan Study.

Wang Z, Wang B, Li X, Zhang S, Wu S, Xia Y.

2020-07-0116 citations

10.1016/j.numecd.2020.06.026

Elevated fasting serum glucose levels increase the risk of hepatocellular carcinoma: A prospective cohort study.

Liu T, Wang W, Cui H, Sun M, Wang Y, Liu X, Cao L, Liu H, Liu S.

2019-07-017 citations

10.1097/md.0000000000016369

Neck circumference is associated with hyperuricemia: a cross-sectional study.

Shen X, Wu S, Xu R, Wu Y, Li J, Cui L, Shu R, Gao X.

2019-04-247 citations

10.1007/s10067-019-04541-1

Aging, Arterial Stiffness, and Blood Pressure Association in Chinese Adults

Shouling Wu, Cheng Jin, Shanshan Li, Xiaoming Zheng, Xinyuan Zhang et al. (7 authors)

Hypertension2019-02-19206 citations

10.1161/hypertensionaha.118.12396

Tea Consumption and Longitudinal Change in High‐Density Lipoprotein Cholesterol Concentration in Chinese Adults

Shue Huang, Junjuan Li, Yuntao Wu, Sareh Ranjbar, Aijun Xing et al. (12 authors)

Journal of the American Heart Association2018-06-2530 citations

10.1161/jaha.118.008814

[Normal value and reference value range of brachial-ankle pulse wave velocity among Kailuan study population].

Jingsheng Gao, Lu Song, Yujiao Wu, Xiaoming Zheng, Xujing Zhao et al. (12 authors)

PubMed2016-12-241 citations

10.3760/cma.j.issn.0253-3758.2016.12.011

[Association between the cardiovascular health score and new-onset atrial fibrillation].

Jihong Shi, Aijun Xing, Y Z Wang, Chengcheng Ji, Chuangshi Zhu et al. (7 authors)

PubMed2016-08-24

10.3760/cma.j.issn.0253-3758.2016.08.014

Interventions

Observational group:None

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Individual aged 18 years and above; 2. Participated in health examination sponsored by Kailuan (Group) Co., Ltd. from June 2006 to September 2007; 3. With completed baseline data.

Exclusion criteria

Exclusion criteria: 1. Baseline data missing; 2. Patients with severe disease and can not be followed up; 3. Those who have already experienced outcome events before the study will be excluded.

Design outcomes

Primary

Measure	Time frame
Cardiovascular diseases, cerebrovas diseases;	—

Secondary

Measure	Time frame
Blood pressure ;Blood glucose;Llipid profiles ;Obesity;Inflammatory markers, such as hypersensitive C-reactive protein, neutrophil / lymphocyte ratio, etc.;Albumin;Iron-related biomarkers ;Arterial stiffness ;Other non-communicable disease markers (e.g. ankle-brachial index);Fundus diseases ;Dietary habit;Brain Structure;Height ;Weight ;Neck circumference;Waist circumference ;Erythrocyte ;Leukocyte;Hemoglobin;Bilirubin;Urea;Creatinine;Uric acid;Urinary protein ;Age ;Gender;Race;Marital status;Education level ;Economic level ;Psychosocial factors;Mental condition;Cognitive level testing;Lifestyle, including sleep duration and quality, smoking, drinking, diet, physical exercise, etc.;Personal history and disease history include cardiovascular and cerebrovascular diseases, hypertension, hyperlipidemia, diabetes, obesity, etc.;Emerging malignant tumor events ;Chronic kidney disease;Fragility fracture event;Mortality;Cerebral small vessel disease;Antihypertensive drugs, hypoglycemic drugs, lipid-lowering drugs and other chronic disease drugs;Nonalcoholic fatty liver;The exposure of Famine in China;The exposure of the Tangshan earthquake;	—

Measure

Time frame

Blood pressure ;Blood glucose;Llipid profiles ;Obesity;Inflammatory markers, such as hypersensitive C-reactive protein, neutrophil / lymphocyte ratio, etc.;Albumin;Iron-related biomarkers ;Arterial stiffness ;Other non-communicable disease markers (e.g. ankle-brachial index);Fundus diseases ;Dietary habit;Brain Structure;Height ;Weight ;Neck circumference;Waist circumference ;Erythrocyte ;Leukocyte;Hemoglobin;Bilirubin;Urea;Creatinine;Uric acid;Urinary protein ;Age ;Gender;Race;Marital status;Education level ;Economic level ;Psychosocial factors;Mental condition;Cognitive level testing;Lifestyle, including sleep duration and quality, smoking, drinking, diet, physical exercise, etc.;Personal history and disease history include cardiovascular and cerebrovascular diseases, hypertension, hyperlipidemia, diabetes, obesity, etc.;Emerging malignant tumor events ;Chronic kidney disease;Fragility fracture event;Mortality;Cerebral small vessel disease;Antihypertensive drugs, hypoglycemic drugs, lipid-lowering drugs and other chronic disease drugs;Nonalcoholic fatty liver;The exposure of Famine in China;The exposure of the Tangshan earthquake;

—

Countries

China

Contacts

Public ContactShouling Wu

Kailuan Group Co., Ltd. Hospital/Kailuan General Hospital

drwusl@163.com+86 315 3025655

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 24, 2026