Skip to content

Effects of dopamine D2 receptor gene polymorphisms on response to clozapine in schizophrenic patients

Effects of dopamine D2 receptor gene polymorphisms on response to clozapine in schizophrenic patients

Status
Active, not recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-TNRC-11001290
Enrollment
Unknown
Registered
2011-03-15
Start date
2009-03-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Interventions

Group A:Patients with 957 C/C treated with Clozapine for 8-weeks
Group B:Patients with 957 C/T treated with Clozapine for 8-weeks
Group C:Patients with 939 C/C treated with Clozapine for 8-weeks
Group D:Patients with 939 C/T treated with Clozapine for 8-weeks
Group E:Patients with 939 T/T treated with Clozapine for 8-weeks

Sponsors

Institute of Clinical Pharmacology,Central South University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
35 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Chinese,male,age from 18-65; 2. Subjects with schizophrenia met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM IV, American Psychiatric Association, 1994) criteria for diagnosis; 3. Not receiving any antipsychotics drugs in a month before accepted in hospital; 4. Not merges other mental illness.

Exclusion criteria

Exclusion criteria: 1. Patients were excluded if they had clinically significant organic or neurological disorders, mental retardation, epilepsy, psychiatric disorders other than schizophrenia; 2. Patients were excluded if with a history of alcohol and drug abuse in the previous 12 months.

Design outcomes

Primary

MeasureTime frame
PANSS scale;

Countries

China

Contacts

Public ContactJie Liu, Peng Li
liujiezhj@126.com+86 731 84805380

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026