Breast cancer
Conditions
Interventions
2:routine modified radical mastectomy
1:routine modified radical mastectomy
Sponsors
West China hospital, SCU
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: NAC+I group (meet each criteria): 1. Single or multiple mass in breast confirmed by Breast high-frequency Doppler and mammography, whose diameter is >=4 cm and 2cm away from nipple; 2. No nipple discharge, erosion or pathologic papillary retraction and invagination. No skin invasion of neoplasm; 3. Hollow needle biopsy showed invasive carcinoma or intraductal carcinoma, negative result of intraoperative frozen section of enlarged lymph node or Sentinel lymph node biopsy; 4. No immune disease; 5. Patients who voluntarily accept breast construction and are able to afford the expense of implantation body and complied the follow-up well; 6. Relative small breast and breast appearance is not satisfying after breast conserving operation. NAC+II group (meet each criteria): 1. Single or multiple mass in breast confirmed by Breast high-frequency Doppler and mammography, whose diameter is >=4 cm and 2cm away from nipple. MRI showed no NAC invasion; 2. No nipple discharge, erosion or pathologic papillary retraction and invagination. No skin invasion of neoplasm; 3. Hollow needle biopsy showed invasive carcinoma or intraductal carcinoma, axillary lymph nodes is less than 4; 4. No immune disease; 5. Abdominal color Doppler, chest x ray or total bone scan show no distant metastasis; 6. Patients who voluntarily accept breast construction and are able to afford the expense of implantation body and complied the follow-up well; 7. Relative small breast and breast appearance is not satisfying after breast conserving operation.Conserving skin and removing nipple I group (meet each criteria) 1. Single or multiple mass in breast confirmed by Breast high-frequency Doppler and mammography, whose diameter is <4 cm and 1-2 cm away from nipple. There is no finding of enlargement or abnormal structure ipsilateral axillary lymph node; 2. No nipple discharge, erosion or pathologic papillary retraction and invagination. No skin invasion of neoplasm. Suspicious or confirmed NAC invasion by MRI; 3. Hollow needle biopsy showed invasive carcinoma or intraductal carcinoma, axillary lymph nodes is less than 4; 4. No immune disease; 5. Abdominal color Doppler, chest x ray or total bone scan show no distant metastasis.
Exclusion criteria
Exclusion criteria: 1. Abdominal color Doppler, chest x ray or total bone scan showed distant metastasis; 2. Inflammatory breast cancer; 3. Immune disease; 4. Tumor invaded skin except nipple and areola papillaris.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3 yrs and 5 yrs local tumor recurrent rate, tumor-free survival, quality of life and total survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-satisfying score of breast appearance;Complication; | — |
Countries
China
Contacts
Public ContactQing Lv
Outcome results
None listed