Retinitis Pigmentosa (RP)
Conditions
Interventions
Typical RP group:Intravitreous Injection for typical Retinitis pigmentosa Intravitreous Injection for typical ietti crystalline corneoretinal dystrophy
Bietti crystalline corneoretinal dystrophy group:Intravitreous Injection for typical Retinitis pigment
Sponsors
Southwest Hospital, Third Military Medical Universi
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Clinical condition, bilateral expression of advanced typical retinitis pigmentosa and Bietti crystalline corneoretinal dystrophy (a form of autosomal recessive retinitis pigmentosa); 2. Age range 18 to 50 years; 3. Visual acuity is better than 20/200 and worse than 20/30 by ETDRS vision testing in the operated eye, or the radius of view is better than10 degree less than 30 degree by visual field testing. Vision in the non-operated eye must be better than the operated eye; 4. Patient has signed informed consent for NGF intravitreous injection and is willing to return for follow-up visits; 5. Macular has no detectable gross changes either clinically or on fluorescein angiography.
Exclusion criteria
Exclusion criteria: 1. Patient has medical problems that have a high risk of general anesthesia, such as metabolic, cadiovascular, hematopoietic or psychological system disorders; 2. Women in menstruation, pregnancy, perinatal prtiod and baby nursing periods; 3. Any significant ocular disease that has compromised or could compromise vision in the study eye and confound analysis of the primary outcome; 4. Patient who has a history of corneal leukoma, cataract, uveitis, Coat's disease, diabetic retinopathy, glaucoma, or vitreous opacities that prevents visualization of the posterior pole; 5. Participating in another ophthalmic clinical trial or use of any other investigational new drugs within 3 months before the start of study treatment; 6. Intraocular surgery within the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Flash electroretinography;Multifocal electroretinography;Pupillary light reflex;Optical coherent tomography;Fluorescein angiography;Static perimetry;Snellen Visual acuit; | — |
Countries
China
Contacts
Public ContactYin Zhengqin
Outcome results
None listed