Advanced retinitis pigmentosa
Conditions
Interventions
Group 2:fetal photoreceptor progenitor cells transplantation
Group1:fetal neuroretinal cells transplantation
Sponsors
Southwest Hospital, Third Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Clinical condition, bilateral expression of advanced retinitis pigmentosa; 2. Age range 18 to 50 years; 3. Visual acuity is worse than 10/200 by ETDRS vision testing in the operated eye, or the radius of view is less than 100 by visual field testing. Vision in the non-operated eye must be better than the operated eye; 4. Patient has signed informed consent for retinal transplantation and is willing to return for follow-up visits; 5. Macular has no detectable gross changes either clinically or on fluorescein angiography.
Exclusion criteria
Exclusion criteria: 1. Patient has medical problems that have a high risk of general anesthesia, such as metabolic, cadiovascular, hematopoietic or psychological system disorders; 2. Women in menstruation, pregnancy, perinatal prtiod and baby nursing periods; 3. Any significant ocular disease that has compromised or could compromise vision in the study eye and confound analysis of the primary outcome; 4. Patient who has a history of corneal leukoma, cataract, uveitis, Coat's disease, diabetic retinopathy, glaucoma, or vitreous opacities that prevents visualization of the posterior pole; 5. Participating in another ophthalmic clinical trial or use of any other investigational new drugs within 3 months before the start of study treatment; 6. Intraocular surgery within the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Static perimetry;Flash electroretinography;Multifocal electroretinography;Snellen Visual acuity;Optical coherent tomography;Fluorescein angiography;Pupillary light reflex; | — |
Secondary
| Measure | Time frame |
|---|---|
| Transplantation rejection; | — |
Countries
China
Contacts
Public ContactYin Zhengqin
Outcome results
None listed