pain and analgesia
Conditions
Interventions
10:eight dose levels of remifentanil were chosen before the study was started, ranging from 0.05 ug/kg.min to 0.4ug/kg.min according to clinical trials and relevant literatures reported previously. Th
10:0. 05ug/kg.min (10%), 0.10 ug/kg.min (15%), 0.15ug/kg.min (30%), 0.20ug/kg.min (40%), 0.25 ug/kg.min (55%), 0.30 ug/kg.min (70%), 0.35ug/kg.min (90%) and 0.4 ug/kg.min (99%).
Sponsors
Department of Anesthesiology, The First Hospital, China Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All patients aged between 20 to 65yr with an American Society of Anesthesiologists physical status (ASA) I-II undergoing elective breast cancer surgery.
Exclusion criteria
Exclusion criteria: (1) immediate extubation was not planned after surgery; (2) they regularly took analgesics or had a history of drug or alcohol abuse; (3) they had used any drug which may interfere the results within 24h of surgery or poorly controller hypertension; (4) they had a history of cardiovascular and cerebrovascular diseases, or psychiatric disorder, or obesity (BMI>30). Pregnant patients were also excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain detectin threshold;pain detectin threshold; | — |
Secondary
| Measure | Time frame |
|---|---|
| posterior response probability; | — |
Countries
China
Contacts
Public ContactHong Ma
Outcome results
None listed