Efficacy of low-dose bisoprolol in maintenance hemodialysis patients with asymptomatic left ventricular remolding and diastolic dysfunction

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-TNC-11001437

Enrollment

Unknown

Registered

2011-06-19

Start date

2009-05-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

end stage renal disease

Interventions

1:oral administration bisoprolol

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients receiving maintenance hemodialysis (4-4.5 hours for each session, tiw) for more than 1 year; diagnosed with left ventricular diastolic dysfunction by echocardiogram for more than six months; BP < 140/80mmHg during hemodialysis without taking antihypertensive drugs; without previous cardiovascular diseases (congestive heart failure, acute myocardial infarction, cerebrovascular accident or peripheral arterial failure)

Exclusion criteria

Exclusion criteria: 1. Malignant diseases; 2. Active infection; 3. Sinus bradycardia (HR<60 times/min); 4. Significant valvulopathy (valve prosthesis, any degree of mitral or aortic stenosis and moderate to significant mitral, aortic or tricuspid regurgitation); 5. Pericardial effusion; 6. Bronchial asthma; 7. Technically unsatisfactory echocardiogram.

Design outcomes

Primary

Measure	Time frame
blood pressure;posterior wall thickness;cardiothoracic ratio;left ventricular diastolic dimension;heart rate;	—

Secondary

Measure	Time frame
cardiothoracic rati;	—

Countries

China

Contacts

Public ContactYiwen LI

yiwen1962@zju.edu.cn+86 0571 87236873

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026