Nasopharyngeal Carcinoma
Conditions
Interventions
1:Neoadjuvant Chemotherapy + IMRT Combined with Cetu
Sponsors
Cancer Center of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1. Histologic diagnosis of nasopharyngeal carcinoma; 2. Aged between 18 and 69 years; 3. T3-4,N0-2,M0 (AJCC 2009); 4. KPS>=80; 5. No distant metastasis; 6. WBC count>=4*10^9/L, Hemoglobin>=100g/L, platelet count>=100*10^9/L; 7. ALAT or AST<1.5*ULN, bilirubin<1.5*ULN; 8. Serum creatinine<1.5*ULN.
Exclusion criteria
Exclusion criteria: 1. Distant metastases; 2. Previously treated (surgery, chemotherapy, radiotherapy, EGFR targeted therapy or immunotherapy); 3. Second malignancy within 5 years; 4. Precious therapy with an investigational agent; 5. Uncontrolled seizure disorder or other serious neurologic disease; 6. Allergic reaction (>=Grade III) to any drug including in this study; 7. Clinically significant cardiac or respiratory disease; 8. Creatinine clearance <30ml/min; 9. Drug or alcohol addiction; 10. Do not have full capacity for civil acts; 11. With severe complications or active infection; 12. Concurrent immunotherapy or hormone therapy for other diseases; 13. Pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute Toxicity;Efficacy in three month; | — |
Secondary
| Measure | Time frame |
|---|---|
| quality of life;the relationship between patient outcome and gene;one and three years locoregional failure-free rate; | — |
Countries
China
Contacts
Public ContactChong ZHAO, Yunfeng ZHOU
Outcome results
None listed