End stage renal failure, renal transplantation
Conditions
Interventions
Study group:irradiation, ATG, Renal and Hematopoietic-Cell Transplantation
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patient fully informed, signed informed consent; 2. Patient is receiving first renal transplant: living related; 3. HLA match 3 to 6 locus, PRA=40 kg.
Exclusion criteria
Exclusion criteria: 1. Patient previously received/receiving transplant other than kidney; 2. Weight 30; 3. Recipient/donor is ELISA positive for human immunodeficiency virus (HIV), antibody positive for hep. C, or surface antigen positive for hep. B; 4. Recipient/donor is positive for TB; 5. Patient has current uncontrolled infections; 6. Patient has current malignancy or history of malignancy within past 5 years; 7. Patients has significant liver disease; 8. Patients has significant cardiac or lung disease; 9. CMV/EBV negative recipients of CMV/EBV positive donor; 10. Patient does not have good compliance and agree to follow-up regularly.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver function;Chimerism;Renal function;Lymphocyte cytotoxicity;Biopsy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Urine routine;CsA C0,C2;MMF AUC;Blood routine and lymphocyte type; | — |
Countries
China
Contacts
Public ContactTongyu Zhu
Outcome results
None listed