Refractory Systemic Lupus Erythematosus
Conditions
Interventions
treating group:using allogeneic bone marrow mesenchymal stem cell transplantation
Sponsors
Nanjing University Medical College Affiliated Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
15 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. all patients fulfilled the American College of Rheumatology (ACR) criteria of SLE, man or woman aged from 15 to 70 years old, SLEDAI>=8; 2. refractory lupus nephritis, 24h urineprotein>=1g; 3. maintain prednisone more than 20 mg/day; 4. ineffective for cyclophosphamide 0.4~0.6/m2 every two weeks for six months, or other immunosuppressive drugs, such as MMF 2 g/day, for three months; 5. patients must sign an informed consent indicating that they are aware of the investigational nature of the study in keeping with the policy of the hosipital.
Exclusion criteria
Exclusion criteria: 1. abnormal liver function (ALT higer than 3 times the normal value); 2. end-stage renal failure patients; 3. patients who have a severe heart and pulmonary failure, or other important organs damage; 4. undercontrolled infections; 5. pregnant or breast feeding women, male or female who intended to recent pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour proteinuria, urine routine, renal function;liver function; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood routine, ES; | — |
Contacts
Public ContactSun Lingyun
Outcome results
None listed