cancer pain
Conditions
Interventions
Group A:use oxycodone hydrochloride controlled-release tablets for titration
Group B:use Immediate release morphine for titration
Sponsors
Department of Head and Neck/Thoracic Medical Oncology; The First People's Hospital of Foshan
Eligibility
Sex/Gender
All
Age
19 Years to 74 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years; 2. Tumor patients who was confirmed by pathology or cycology diagnosis; 3. moderate to sereve pain intensity; 4. patients with clear mind; able to understand the therapeutic regimen.
Exclusion criteria
Exclusion criteria: 1. Patients during pregnant stage and breast-feed stage; 2. Pain related to an oncologic emergency: Bone fracture or impending fracture of weight-bearing bone; Neuroaxial metastases with threatened neural injury; Infection; Obstructed or perforated viscus (acute abdomen); 3. patient with opioid contraindications; 4. patients with severe liver or kidney dysfunction (ALT/AST/creatinine/usea nitrogen was three times higher than normal value); 5. patients with a history of drug or alcohol abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with NRS=3 during the previous 24 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| proporation of patients with a clinically meaningful (=30%) reduction of pain intensity from baseline;the NRS scores at 12h, 24h, 36h, 48h, 60h, 72h;the dose of oxycodone at 12h, 24h, 36h, 48h, 60h, 72h;the times of breakthrough pain at 12h, 24h, 36h, 48h, 60h, 72h;Assessment the quality of life in patient;Record the adverse event;Patient satisfaction assessment; | — |
Countries
China
Contacts
Public ContactFeng Weineng
The First People's Hospital of Foshan
Outcome results
None listed